Diamond Protein L

Product Characteristics

High rigid agarose base matrix, enabling high flow velocity and improved productivity.
Highly specific Kappa light chain, enabling efficient capture of antibody and antibody fragments with wide selection.
High binding capacity, reduce production time and resin consumption, lower cost and improved productivity.

Diamond CD-S

Novo-A Diamond

Description

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1. Introduction

Diamond Protein L is an innovative affinity resin obtained by coupling Protein L ligands on the highly rigid agarose base matrix via epoxy activation. Its highly rigid agarose enjoys higher flow velocity and lower back pressure than conventional resins. Besides, the variable zone between the Protein L ligands and Kappa antibody light chain possesses strong affinity. It is also suitable for the capture of antibody fragments, including Fab, single chain antibody fragment(scFv) and regional antibody(dAbs), from large-volume cell culture media.

Advantages：

High rigid agarose base matrix, enabling high flow velocity and improved productivity.

Highly specific Kappa light chain, enabling efficient capture of antibody and antibody fragments with wide selection.

High binding capacity, reduce production time and resin consumption, lower cost and improved productivity.

2. Technical Characteristics

Appearance	White slurry, can be layered
Matrix	High rigid agarose
Average particle size⁺	~80μm
Functional group	Recombinant Protein L(from E.coli)
Cross-linking method	Epoxy chemistry
Dynamic binding capacity⁺⁺	~40 mg Human IgG/mL packed resin（Retention time 6min）
Chemical stability	Common aqueous solutions：10mM HCl、0.1M citric acid（pH3）、6M Urea、6M GuHCl、30% isopropanol、20%ethanol
Max. pressure	0.5MPa
Pressure flow velocity	≥300cm/h，
pH stability	2~10（working），15mM NaOH（CIP）
Storage⁺⁺⁺	2~8℃，20% ethanol or 2% benzyl alcohol

+ Particle size is normally distributed, average particle size is the medium value of the particle size in resin

++Flow velocity 100cm/h，bed height 10cm，Buffer solution：20mM PB、0.15M NaCl，pH7.2

+++2% benzyl alcohol is only used for international transport or special requirements from customer

3. Order Information

Product	Code No.	Pack size
Diamond Protein L	AA05101	25mL
	AA05102	100mL
	AA05103	500mL
	AA05104	1L
	AA05105	5L
	AA05106	10L

Prepacked columns	Code No.	Pack size
EzFast Diamond Protein L	EA05121	1×1mL
	EA05123	1×5mL
	EA05131	5×1mL
	EA05133	5×5mL
EzScreen Diamond Protein L	EA05125	1×4.9mL
EzScreen Diamond Protein L	EA05135	5×4.9mL
EzLoad 16/10 Diamond Protein L	EA05101	1 pcs
EzLoad 26/10 Diamond Protein L	EA05111	1 Pcs

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