BXK300 Industrial scale chromatography column

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1. Introduction

BXK300 series chromatographic column is a high precision sanitary chromatographic column specially designed for the large-scale production of biomolecule drugs. It is suitable for the packing of resins in low pressure chromatographic columns.

BXK chromatography column is composed of three parts: adaptor, column body and stand. The basic structure includes glass tube, flange, O-ring, screens, support nets, deflector ,end-piece and rods. The rods hold the flange and end-piece to the glass tube which is sealed by O-rings. The O-ring can not only avoid the direct contact between the glass tube and the end-piece, but also ensure the sealing of the glass tube.

The adaptor and end-piece are designed for single pipe use. The adaptor and end-piece are covered with a large pore support net, a fine pore screen and deflector. When choosing screen, screen with different pore sizes (23μm (polypropylene) or 10μm (nylon)) are available.

Different column heights can be set by adjusting the height of adaptor. The column can be sealed by compressing or loosening the seal ring.

The end-piece is mounted on the stand, which is equipped with a universal wheel for easy movement. The foot brake on the universal wheel can fix the column.

The BXK300 series chromatography column is a glass chromatography columns developed for industrial scale purification .All materials used meet the requirements of SFDA for pharmaceutical manufacturers, so it is an ideal choice for industrial production. Listed are main characteristics the column:

① Column body is made of medical grade 316L stainless steel.

② The glass part of tube body is made of imported high-precision medical glass, of which roundness error is less than 0.1mm.

③ Screen, support nets and deflector are made of imported materials, enable tolerance with a variety of acid /alkali solutions and organic solvents;

④ O-ring made of EPDM material, offering better sealing and durability.

⑤ Adaptor which enables adjustable bed height.

All parts of the chromatography column have complete material certification, meeting requirements of pharmaceutical industry.

2. Technical Characteristics

Specifications	Diameter (mm)	Floor area (cm²)	Column Height (cm)	Bed height（cm）		Volume(L)		Max Pressure (bar/g)	Total weight (kg)	Chromatographic column inlet dimension	Adaptor weight (kg)	Outline dimension (cm) D×W×H
Specifications	Diameter (mm)	Floor area (cm²)	Column Height (cm)	Min	Max	Min	Max	Max Pressure (bar/g)	Total weight (kg)	Chromatographic column inlet dimension	Adaptor weight (kg)	Outline dimension (cm) D×W×H
BXK300/500	296	688	50	0	33	0	22.7	4.0	68	10mm	29	69×69×135
BXK300/750	296	688	75	25	54	17.2	37.2	4.0	73			69×69×160
BXK300/950	296	688	95	45	72	31.0	49.6	4.0	78			69×69×180

Specifications	Supporting net	Screen	Column tube	Seal ring	Deflector	Holder
BXK 300/500	PP	10μm nylon（PA） 23μm PP	Glass	EPDM	PP	316L stainless steel
BXK 300/750
BXK 300/950

3. Order Information

Product	Art.No.	Package/piece
BXK300/500（10um）	BC836211	1
BXK300/500	B-300500	1
BXK300/750（10um）	BC838211	1
BXK300/750	B-300750	1
BXK300/950（10um）	BC839211	1
BXK300/950	B-300950	1
Adaptor O-ring (300 columns)	BS830012	2
10μm Net,adaptor (300 columns)	BS820012	2
10μm Net, end piece (300 columns)	BS820032	2
23μm Net,adaptor (300 columns)	BS820022	2
23μm Net, end piece (300 columns)	BS820042	2
Support net,adaptor（300columns）	BS820052	2
Support net, end piece（300columns）	BS820062	2
Glass tube (300/500 columns)	BS816001	1
Glass tube (300/750 columns)	BS818001	1
Glass tube (300/950 columns)	BS819001	1
Four-point two-way valve, 6mm	B-006	1
Four-point two-way valve, 10mm	B-010	1
Four-point four-way valve, 6mm	BA210021	1
Four-point four-way valve, 10mm	BA220021	1
1 "stainless steel clamp	B-0011	1
1 "stainless steel clamp	BA500016	10
Gasket (TC25, 6.9mm)	B-018	2
Gasket (TC25, 6.9mm)	BA500036	10
Gasket (TC25, 12.5mm)	BA500052	2
Gasket (TC25, 12.5mm)	BA500056	10
Blind board (TC25)	B-019	2
Blind board (TC50)	BA500072	2
Pressure gauge（TC25 interface,6bar）	BA500081	1
Pressure gauge（TC25 interface,10bar）	BA500091	1
Pressure gauge（TC50 interface,6bar）	BA500191	1
Pressure gauge（TC50 interface,10bar）	BA500181	1
Three-way（TC25Stainless steel T type）	BA500101	1
Three-way（TC25/TC50Stainless steel T type）	BA500111	1
TC joint PVC pipe,6mm,1.5M	B-0013	1
TC joint PVC pipe,6mm,2M	BA187001	1
TC joint PVC pipe,10mm,1.5M	B-0014	1
TC joint PVC pipe,10mm,2M	BA197001	1
TC connector silicone pipe,6mm,1.5M	B-0015	1
TC connector silicone pipe,6mm,2M	BA187011	1
TC connector silicone pipe,10mm,1.5M	B-0016	1
TC connector silicone pipe,10mm,2M	BA197011	1
Glue stick（80mmplate）	BA500011	1
Glue stick（150mmplate）	BA500021	1
300 Reservoir	B-300-01	1
end-piece O-ring（300columns）	BS830021	1
Adaptor O-ring（300columns）	BS830031	1
Feed port O-ring（300columns）	BS830041	1
Adaptor plate（300 columns）	B300500-34	1
End-piece（300columns）	B300500-12	1
Outer adaptor tube（300columns）	B300500-31	1
Adjuster nut, insert（300columns）	B300500-22	1

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