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Weak Cation Exchange Resins

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Ion Exchange Resins
Weak Cation Exchange Resins

CM Bestdex C-25

Product Characteristics

  • CM Bestdex C-25 is a weak cation exchange resin formed by coupling carboxymethyl groups on cross-linked dextran microspheres.
  • CM Bestdex C-25 is based on Bestdex G-25, which has a very high capacity for small molecular substances and is very suitable for the separation and purification of antibiotics, natural products and other substances.
  • It retains the excellent hydrophilicity and pore structure of natural polysaccharide compounds, good compatibility with biologically active molecules, and very low non-specific adsorption.

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1. Introduction 

Ion exchange chromatography(IEC)is a very effective method for separation and purification of biological molecules.The method mainly relies on the interaction between positive and negative charges and uses the nature and difference of the charges carried by different biomolecules under specific conditions to separate.It has the characteristics of high load capacity, good resolution, controllable conditions and easy amplification. It has been widely used in medicine, chemical industry, metallurgy, food and other fields.
The ion exchange resin is composed of three parts：(1)Cross-linked mesh base frame, which is porous, hydrophilic and chemically stable；(2)The functional group fixed on the base frame, which is a charged group, determines the nature of the ion exchange chromatography resin；(3) An ion (called an equilibrium ion) that has an opposite charge to the functional group and can be reversibly bound to the functional group.
CM Bestdex C-25 is a weak cation exchange resin formed by coupling carboxymethyl groups on cross-linked dextran microspheres. It retains the excellent hydrophilicity and pore structure of natural polysaccharide compounds, good compatibility with biologically active molecules, and very low non-specific adsorption.CM Bestdex C-25 is based on Bestdex G-25, which has a very high capacity for small molecular substances and is very suitable for the separation and purification of antibiotics, natural products and other substances. Due to the large variation of the column bed volume of the chromatography resin in different buffers, it is not suitable to be installed as a fixed bed chromatography column.

2. Technical Characteristics

Appearance

White to slight yellow powdery solid

Matrix

Cross-linked dextran

Functional group

Carboxymethyl

Dry powder size

40~120μm

Swelling coefficient

7mL/g dry powder(PBS)

Ionic capacity

4.0~5.0 mmol H+/g dry powder

Max. pressure

0.3 MPa

Working pH range

6~10

pH stability

2~13(CIP),2~12 (working)

Chemical Stability

Stable in common aqueous buffers: 6M GuHCl,8M Urea, 70% ethanol , 30% isopropyl alcohol

Temperature tolerance

Working temperature:2~40℃, Can't freeze, Can tolerate 121℃ high pressure sterilization (50mM PB pH 7)

Recommended flow velocity

60~150cm/h
 

3. Order Information

Product

Code No.

Pack size

CM Bestdex C-25

AI0261

25g

AI0262

100g

AI0263

500g

AI0264

1kg

AI0265

5kg

AI0267

10kg

AI0268

20kg

AI0266

25kg
 

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