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Established in 2008, Bestchrom is a high-tech enterprise focusing on the production of high-quality chromatography resin. As one of the earliest chromatography resin providers on large scale in China, Bestchrom offers various chromatography solutions from resin, pre-packed column, lab-scale column, processing-scale column to micro-carrier in addition to its tailor-made services including process development and resin customization.
After more than a decade’s technology accumulation and production practice, the company now has three R&D platforms covering matrix R&D, chemical ligand R&D and protein ligand R&D. Besides, the company’s three matrix production platforms consist of dextran matrix, agarose matrix and polymer matrix platforms.
Currently, its huge output(more than 1000L/batch) and excellent batch-to-batch consistency guarantee the quality and stable resin supply for bio-pharmaceuticals, which further contributes to supply chain security for customers in the field of antibodies, vaccines, gene therapy, recombinant proteins, peptides, blood products, enzyme preparation and natural substances. Bestchrom will continue to innovate and provide stable, quality and user-friendly solutions to improve their core competitiveness.
•Check certificates for all materials
•Establish supplier management left documents database
•QC testing for every batch of raw materials received
•Guarantee regulation obedience during the whole production process
•Sample testing for semi-finished and finished products
• Inspections on batch, products stability, packing materials
• A database including more than 400 documents, 130 tables, and records.
• Independent sample rooms dedicated to sample inspection
• Quality tracing & performance stability study.
Agarose-based resins platform
Agarose matrix enjoys hydrophilicity, good stability, controllable pore size and particle size. Thus, it is extremely suitable for separation and purification of bio-molecules. The advanced emulsification and crosslinking technologies of Bestchrom enable the production of agarose-based resins with various bead sizes, rigidity and coupled ligands, meeting specific purification needs from customers.
Dextran-based resins platform
Resins in this category are based on biologically inert dextran matrix via epichlorohydrin cross-linking. The product enjoys hydrophilicity, porousness, low non-specific adsorption and easy swelling. Microspheres with different swellability and pore sizes can be obtained by controlling cross-linking degree. In addition to the size exclusion chromatography function, dextran-based SEC resins can also serve as base matrix for ionic functional groups and cell-cultural micro-carriers.
PSDVB resins platform
Styrene and divinylbenzene polymers based resins enjoys excellent mechanical property. The matrix is featuring in high rigidity, low back pressure, high flow rate , high resolution and easy linear scale-up, providing the resins with broad application prospect in the chromatography purification. After hydrophilic treatment, the resins obtain low non-specific adsorption and excellent chemical stability, enabling broad purification applications when coupled with different functional groups.
Chemical ligands platform
Chemical ligands play a key role in the determination of resin function. By choosing ligands with different electric charge properties, charge strength, hydrophobicity and specific adsorption performances, as well as base matrix made from different materials, Bestchrom resins can achieve different functions. Customers are more than welcomed to get their tailor-made resins by choosing the right combination.
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