Bestchrom will participate in CPHI Milan 2026 from October 6–8, showcasing Novo-A Diamond, Diamond CD-S, and other chromatography resins for biopharmaceutical purification.

Discover how pore structure defines the performance boundaries of chromatography resins. Learn how pore design affects binding capacity, mass transfer, resolution, and mechanical strength, and why balancing these properties is essential for successful bioprocess development and industrial-scale purification.

This article explains the possible causes of elevated chromatography column pressure, including viscosity changes, system restrictions, resin deformation, and actual fouling. It also provides a systematic troubleshooting workflow and targeted CIP strategies for different types of contaminants.

As upstream antibody titers continue to rise, downstream purification faces unprecedented productivity challenges. Although continuous chromatography and membrane chromatography offer important advantages, conventional column chromatography remains the cornerstone of industrial antibody purification because of its high binding capacity, excellent reusability, and superior separation performance.

Chromatography resins are engineered through coordinated design of the matrix, ligand, and coupling chemistry. Their performance reflects a series of trade-offs among capacity, selectivity, mass transfer, pressure, stability, and scalability. Effective resin selection therefore depends on matching the resin’s design intent and performance boundaries to the specific requirements of capture or polishing processes.

Exosomes are attracting growing interest in regenerative medicine, cell therapy, and drug delivery. As production moves toward industrialization, scalable purification has become a key challenge. This article reviews the transition from laboratory isolation methods to chromatography-based purification strategies, including SEC, AEX, and mixed-mode chromatography.

This article explores the molecular mechanisms underlying non-specific binding (NSB) in protein chromatography. By examining NSB from the perspectives of molecular thermodynamics and resin–protein interfacial dynamics, it discusses the key factors influencing NSB and practical strategies for minimizing its impact on purification performance.

This joint white paper explores how next-generation Protein A resins enable mild-pH elution, enhanced aggregate control, and greater process flexibility in bispecific antibody purification. Using industrially relevant material, the study demonstrates up to 66.93% aggregate reduction, improved monomer purity, wider operating windows, and robust performance for scalable biomanufacturing.

Bestchrom showcased its latest downstream purification solutions for biopharmaceutical applications at CPHI & PMEC China 2026, highlighting its next-generation Protein A resin and strengthening partnerships with customers worldwide.

Bestchrom will showcase its latest chromatography solutions at CPHI China 2026, featuring Extrem A Diamond, a next-generation alkali-resistant Protein A affinity resin. Designed for efficient antibody purification, it combines high binding capacity, excellent alkali stability, mild elution performance, and scalability for modern bioprocessing applications.

Learn how antibody purification works — from affinity and ion exchange to HIC and gel filtration. Explore purification workflows, capture strategies, and polishing steps for mAb downstream processing.

This article discusses why higher binding capacity is not always better in antibody affinity chromatography. It explores the trade-offs between DBC, flow rate, selectivity, resin lifetime, and process productivity, emphasizing that resin selection should focus on overall process performance rather than capacity alone.

Pre-activated chromatography resins enable efficient ligand coupling for custom affinity purification, offering flexibility, high specificity, and suitability for diverse biomolecule purification workflows.

Bestchrom showcased high-performance chromatography solutions at BIOCHINA 2026, highlighting advanced resins for efficient and scalable bioprocessing.

March 12–14 | Suzhou International Expo Center | Booth E3-061–062. We look forward to meeting you there!

In large-scale manufacturing, chromatography resins are not only the core of purification processes, but also critical to cost control and quality assurance. How to select them scientifically?

Ion exchange chromatography resins play a key role in the precise purification of chemical compounds. How do they work? And why have they become indispensable across industries?

This article provides an in-depth analysis of downstream purification strategies for ADCs, the associated technical challenges, and corresponding solutions.

Chromatography, with its high selectivity, scalability, and mild operating conditions, has become a core technology for producing raw materials used in IVD applications.