What exactly are Protein A affinity resins, and why are they such a big deal in biotech and pharmaceutical manufacturing?

Bispecific antibodies (BsAbs) enjoys great potential in tumor immunotherapy as a result of their multi-target mechanism.

CPHI & PMEC China 2025, also known as PMEC China, took place in Shanghai New International Expo Centre (SNIEC) from June 24th-26th,2025. The three-day event has attracted more than 3500 pharmaceutical products manufacturers and about 100,000 visitors.

HIC, as the key step in bsAb purification, shows unique advantage in the removal of aggregates. By selecting the right resin type and optimizing processing parameters, it is possible to achieve the efficient separation of target molecules from impurities, leading to high purity and recovery of target proteins. HIC resins play a key role in the scale-up of bsAb production.

In the downstream processing of bio-pharmaceuticals, Ion exchange chromatography(IEX) enjoys advantages such as high resolution, large processing volume, easy operation and wide application, making it

Being a global pharmaceutical event, CPHI & PMEC China 2025 will take place in Shanghai New International Expo Centre (SNIEC) from June 24th-26th,2025. 

Known as "biological missiles" for tumor treatment, Antibody-drug conjugates (ADCs) uses antibodies to target tumor cells and accurately release cytotoxic loads.

Ion exchange chromatography resins play a key role in the precise purification of chemical compounds. How do they work? And why have they become indispensable across industries?

AEX chromatography resin is now a key link in the processing of viral vector purification, thanks to its advantages including high resolution, stable operation and easy scale-up. IEX is playing an indispensable role in vaccine production and preparation of gene therapy. As chromatography technology and resin performance continuously updates, AEX will continue to be a crucial part in the R&D of viral vectors production process.

The purpose of this article is to introduce four chromatography methods in terms of separation principle, advantages, applicable scenarios and tips for resin selection, so as to promote your process development and technical understanding.

In this article, an innovative Protein A based approach for the effective removal of aggregates will be shared and introduced.

Purification serves as a key step in the antibody drug production. Traditionally, ion exchange chromatography mainly relies on salt gradient for elution. In recent years, high liner pH gradient is showing better selectivity and purification effectiveness.

Mixed-mode chromatography (MMC), also known as multimodal chromatography, encompasses chromatographic techniques employing multiple types of interactions between the stationary phase and analytes to achieve efficient separation.

Chromatography resins can be categorized into affinity resin, ion exchange (IEX) chromatography resin, and hydrophobic interaction chromatography (HIC) resin, etc.

Comparability study serves as the foundation and key to the success of the pharmaceutical changes evaluation in biological products.

In addition to the specific enrichment of low abundance protein in complex condition, it can boost yields of target protein as well as bring new property to target proteins.

Bestchrom has successfully provided downstream purificiaiton solutions for multiple recombinant herpes zoster vaccines, including purification process development and allied resins.

Pathogens and their metabolites can serve as an immunological formulation to prevent or treat infectious diseases in the manner of artificial attenuation, detoxification, inactivation, or genetic engineering methods

In the field of biopharmaceuticals, formation of antibody aggregates has always been a challenge in the production of antibody drugs.

Various purification methods have been involved in the purification of blood products, among which cold ethanol fractionation is regarded as the basic method of large scale plasma purification.