The article explores strategies for removing host cell proteins (HCP) in antibody drug production, focusing on techniques like affinity chromatography, depth filtration, and ion exchange chromatography. Optimizing these methods is crucial for ensuring drug stability and efficacy.

Bispecific antibody (BsAb) is a type of artificial antibody via gene recombination technology.

The appearance of the solution is a must test item for raw material used for injection, which usually includes the clarity, turbidity and color of liquid.

In R&D of bio-pharmaceuticals, rapid optimization of upstream and downstream process conditions, enhanced process efficiency and improved product quality have long been the core goals of R&D team.

Biological products using human or animal materials risk viral contamination from raw materials or additives during preparation and formulation stages.

Endotoxin, an indispensable structural component of the outer membrane of gram-negative bacteria, is a toxic substance released during bacteria

Collagen, as a protein combined with both special structure and function, is widely applicable in biomaterial sectors including pharmaceuticals and aesthetic cosmetics.

Lentivirus, as an excellent viral vector, has been widely used in cellular immunotherapy.

Small nucleic acid drugs(oligonucleotide drugs) belong to the most rapidly developing gene therapies at present.

Size exclusion chromatography(SEC), also known as gel filtration chromatography or steric exclusion chromatography, is a protein isolation technology based on the various molecular weights and shapes of bio-molecules.

IEX resins can be divided into cation exchange resin and anion exchange resin according to the property of electric charges on functional groups.

Glutathione S-transferase (GST) is a multifunctional phase II metabolic enzyme and a macromolecular protein with a molecular weight of 26kDa.

To put it simply, blue resin is an affinity resin using Cibacron Blue 3GA dye molecules as ligands.

Diamond Protein L is a novel affinity chromatography resin obtained by coupling Protein L ligands on highly rigid agarose beads.

The majority of currently available insulin is obtained via genetic engineering synthesis and subsequent purification process, among which, chromatographic technology is most widely used.

As early as 1840s, scientists discovered cytoplasmic genetic factors which can metastasize among cells.

Binding capacity refers to the amount of target molecules a type of resin can bind under certain condition.

According to the list of top-selling drugs worldwide, antibody-based drugs play a dominant role in the market with an ever increasing demand in oncology sector.

After comparing sample purity before/after purification, it is found that AT Protein A Diamond Ultra can effectively remove impurities and improving purity of target antibody.

The established scientific proof helps to ensure the production of products which can consistently meet quality expectation.