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Strong Cation Exchange Resins

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Ion Exchange Resins
Strong Cation Exchange Resins

Diamond SP Mustang XL

Diamond SP Mustang XL

Product Characteristics

  • Strong CEX resin with high resolution
  • High rigid agarose matrix, applicable in the intermediate purification and polishing of samples on production scale.
  • Good mechanical and chemical stability, long working life.
  • Widely applicable in the polishing of macro-biomolecules including recombinant proteins and antibodies in bio-pharmaceuticals and bio-engineering.
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Description
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1. Introduction

Ion exchange (IEX) chromatography is a very effective method for the separation and purification of biomolecule. The method mainly relies on the interaction between positive and negative charges, and uses the charge properties and differences of different biological molecules under specific conditions to separate them. It has the characteristics of high load, good resolution, controllable condition and easy scale-up. It has been widely used in medicine, chemical industry, metallurgy, food and other fields.

IEX resin is composed of three parts: (1) Cross-linked agarose matrix, that has the characteristics of porous, hydrophilic and good chemical stability, through the modification to traditional agarose molecules, it has stronger mechanical properties, which is called high rigid agarose, namely Diamond matrix. (2)Functional groups fixed to the matrix, which are electrically charged groups, determine the properties of the IEX resin. (3)An ion (called an equilibrium ion) that has an opposite charge to the functional group and can be reversibly bound to the functional group.

Based on a high-rigidity agarose microsphere, Diamond SP Mustang XL is obtained by firstly coupling dextran long chain, and then cross-linking sulfopropyl groups on the dextran molecules. This structure reduces the steric hindrance effect between biomolecules and ligands, greatly increasing the dynamic binding capacity of the target molecules.

 

2. Technical characteristics

Appearance

White slurry, can be layered

Matrix

High-rigidity agarose with long dextran chain

Functional group

Sulfopropyl

Average particle size+

36~44μm

Ionic capacity

160~220μmol H+/mL packed resin

Dynamic binding capacity

> 100 mg lysozyme/mL packed resin

Max. pressure

0.5MPa

Chemical stability

Stable in common aqueous buffers: 1M NaOH++, 6M GuHCl, 30% isopropyl alcohol, 70% ethanol

Avoid contact with oxidizing agents, cationic detergents.

pH stability

3~14(CIP), 4~12(working)

Operating temperature

Operating temperature:2~40℃, do not freeze.

Storage+++

2~30℃, 20% ethanol with 0.2M NaAc or 2% benzyl alcohol with 0.2M NaAc

Recommend flow velocity

100~300cm/h

 

+ Average particle size is the accumulated resin particle size of packing volume distribution.

++1M NaOH only be used for cleaning.

+++2% benzyl alcohol is only used for international transport or special requirements from customer.

 

3. Order information

Product

Cat. No.

Pack size

Diamond SP Mustang XL

AI313205

25mL

AI313207

100mL

AI313211

500mL

AI313212

1L

AI313213

5L

AI313214

10L

AI313215

20L

AI313216

40L

 

Prepacked columns

Cat. No.

Pack size

EzFast SP Mustang XL

EI03821

1×1mL

EI313251

5×1mL

EI313203

1×5mL

EI313253

5×5mL

EzScreen SP Mustang XL

EI03825

1×4.6mL

EI03835

5×4.6mL

EzLoad 16/10 SP Mustang XL

EI313204

1 pcs

EzLoad 26/10 SP Mustang XL

EI313206

1 pcs

 

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