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Strong Cation Exchange Resins

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Ion Exchange Resins
Strong Cation Exchange Resins

MegaPoly BXS

MegaPoly BXS

Product Characteristics

  • CEX resin based on polymer matrix
  • High binding capacity and good alkaline stability: for purification of different samples, reduced sample dilution, improved efficiency.
  • High resolution, widely applicable in the intermediate purification and polishing of maro-biomolecules including mAb, BsAb and ADC.
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Description
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1. Introduction

Ion exchange (IEX) chromatography is a very effective method for the separation and purification of biomolecules. The method mainly relies on the interaction between positive and negative charges, and uses the charge properties and number difference of biological molecules under specific conditions to separate them. It has the characteristics of high binding capacity, good resolution, controllable condition and easy scale-up. It has been widely used in medicine, chemical industry, metallurgy, food and other fields.

MegaPoly BXS is a strong cation IEX resin, obtained by coupling the sulfopropyl functional groups on the cross-linked Polystyrene-divinylbenzene base matrix. With an average particle size of 50 μm, the resin possesses a special pore structure, which offers larger pores for flow-through and diffusion. Thus, it can not only provide high flow velocity without compromising bio-molecule binding capacity and selectivity, but also ensure rapid interaction between targeted bio-molecules and functional groups, granting it merits such as high flow velocity, high binding capacity and high resolution. Accordingly, the resin is widely applied in the efficient purification of micro-bio molecules including recombinant protein, monoclonal antibodies, DNA, viruses and peptides, providing it with a promising prospect in the bio-pharmaceutical industry.

The resin has the following features:

● The cross-linked base matrix has strong mechanical resistance and low back-pressure

● Special pore structure enhances interaction between bio-molecules and resin

● High binding capacity, high resolution and fast flow

● Physical and chemical stability

● Option for more efficient purification and separation

 

2. Technical characteristics

Appearance

White slurry

Matrix

Cross-linked polystyrene-divinylbenzene beads

Functional Group

Sulfopropyl

Particle size

~50μm

Dynamic binding capacity +

>100mg Human IgG /mL packed resin

Max.pressure

10MPa

Salt Tolerance

0-5M,all common salts

Chemical Stability

All common solutions: water ,1M NaOH,8M Urea,6M GuHCl,glycol,0-100% ethanol,acetonitrile,2M acetic acid,1M HCl, other common solutions.

pH stability

1~14

Operating temperature

Operating temperature:2~30℃, do not freeze.

Storage

2~30℃,20% ethanol or 0.1M NaOH

Avoid

Avoid exposure to strong oxidants, oxidizing acids, strong reducing agents, acetone or benzyl alcohol.

 

+10%DBC,Buffer A:50mM Sodium acetate,pH5.5,Column bed height 10cm,Flow velocity:100cm/h

 

3. Order Information

Product

Cat. No.

Pack size

MegaPoly BXS

AI05701

25mL

AI05702

100mL

AI05703

500mL

AI05704

1L

AI05705

5L

AI05706

10L

AI05707

20L

AI05708

40L

 

Prepacked columns

Cat. No.

Pack size

EzFast MegaPoly BXS

EI05721

1×1mL

EI05731

5×1mL

EI05723

1×5mL

EI05733

5×5mL

EzScreen MegaPoly BXS 

EI05725

1×4.6mL

EI05735

5×4.6mL

EzSelect MegaPoly BXS

EI05726

8×600μL

EzLoad 16/10 MegaPoly BXS

EI05701

1 pcs

EzLoad 26/10 MegaPoly BXS

EI05711

1 pcs

 

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