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Strong Anion Exchange Resins

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Chromatography Resins
Ion Exchange Resins
Strong Anion Exchange Resins

Q Bestarose BB

Q Bestarose BB

Product Characteristics

  • AEX resin with Big bead size(100~300μm), suitable for the rapid and efficient processing of large feedstock volume.
  • Enable to withstand high flow rate, easy scale-up
  • Good chemical stability, many types of solutions can be used for CIP
  • Widely applicable in the rapid capture of highly viscous sample in bio-pharmaceuticals.
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Description
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1. Introduction

Ion exchange (IEX) chromatography is a very effective method for the separation and purification of biomolecule. The method mainly relies on the interaction between positive and negative charges, and uses the charge properties and differences of different biological molecules under specific conditions to separate them. It has the characteristics of high load, good resolution, controllable condition and easy scale-up. It has been widely used in medicine, chemical industry, metallurgy, food and other fields.

IEX resin is composed of three parts: (1) Cross-linked agarose matrix, that has the characteristics of porous, hydrophilic and good chemical stability. (2)Functional groups fixed to the matrix, which are electrically charged groups, determining the properties of the IEX resin. (3)An ion (called an equilibrium ion) that has an opposite charge to the functional group and can be reversibly bound to the functional group.

The Big Beads resin is obtained by coupling various functional groups on the agarose base matrix with high crosslinking. The large particle matrix can tolerate samples with poor clarity, reducing possibility to plug column. The fast flow velocity is suitable for processing large samples in a short time.

Q Bestarose BB is a strong anion exchange resin, which can capture biological macromolecules directly from the feed stock. The fast flow velocity is suitable for large-scale production applications.

 

2. Technical characteristics

Appearance

White slurry

Matrix

Highly crosslinked agarose

Functional group

Quaternary amine group

Particle size+

100~300μm

Ionic capacity

180~250μmol Cl-/mL packed resin

The exclusion limit, Mr

~4 × 106 (globular protein)

Max. pressure

0.3MPa

Chemical stability

Stable in common aqueous buffers: 1M NaOH++,6M GuHCl,30% isopropanol,70% ethanol

Avoid contact with oxidizing agents.

pH stability

2~14(CIP),2~12 (working)

Operating temperature

Operating temperature:2~40℃, do not freeze.

Storage+++

2~30℃, 20%ethanol or 2% benzyl alcohol

Recommend flow velocity

300~900cm/h

 

+Particle size is normally distributed, and particles within this range account for more than 80% of the total.

++1M NaOH only be used for cleaning.

+++2% benzyl alcohol is only used for international transport or special requirements from customer.

 

8. Order information

Product

Cat. No.

Pack size

Q Bestarose BB

AI204405

25mL

AI204407

100mL

AI204411

500mL

AI204412

1L

AI204413

5L

AI204414

10L

AI204415

20L

AI204416

40L

 

Prepacked columns

Code No.

Pack size

EzFast Q BB

EI02921

1×1mL

EI204451

5×1mL

EI204403

1×5mL

EI204453

5×5mL

EzScreen Q BB

EI02925

1×4.6mL

EI02935

5×4.6mL

EzLoad 16/10 Q BB

EI204404

1 pcs

EzLoad 26/10 Q BB

EI204406

1 pcs

 

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