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BXK450 series chromatographic column is a high precision sanitary chromatographic column specially designed for the large-scale production of biomolecule drugs. It is suitable for the packing of resins in low pressure chromatographic columns.
BXK chromatography column is composed of three parts: adaptor, column body and stand. The basic structure includes glass tube, flange, O-ring, screens, support nets, deflector,end-piece and rods. The rods hold the flange and end-piece to the glass tube which is sealed by O-rings. The O-ring can not only avoid the direct contact between the glass tube and the end-piece, but also ensure the sealing of the glass tube.
The adaptor and end-piece are designed for single pipe use. The adaptor and end-piece are covered with a large pore support net, a fine pore screen and deflector. When choosing screen, screen with different pore sizes (23μm (polypropylene) or 10μm (nylon)) are available.
Different column heights can be set by adjusting the height of adaptor. The column can be sealed by compressing or loosening the seal ring.
The end-piece is mounted on the stand, which is equipped with a universal wheel for easy movement. The foot brake on the universal wheel can fix the column.
The BXK450 series chromatography column is a glass chromatography columns developed for industrial scale purification .All materials used meet the requirements of SFDA for pharmaceutical manufacturers, so it is an ideal choice for industrial production. Listed are main characteristics the column:
① Column body is made of medical grade 316L stainless steel.
② The glass part of tube body is made of imported high-precision medical glass with better smoothness and roundness.
③ Screen, support nets and deflector are made of imported materials, enable tolerance with a variety of acid /alkali solutions and organic solvents.
④ O-ring made of EPDM material, offering better sealing and durability.
⑤ Adaptor which enables adjustable bed height.
All parts of the chromatography column have complete material certification, meeting requirements of pharmaceutical industry.
|
Specifications |
Diameter |
Floor area |
Column Height |
Bed height（cm） |
Column Volume(L) |
Max Pressure |
Total |
Chromatographic column inlet dimension |
Adaptor weight |
Outline dimension |
||
|
Min |
Max |
Min |
Max |
|||||||||
|
BXK450/500 |
446 |
1562 |
50 |
3 |
42 |
4.7 |
65.6 |
2.5 |
200 |
10mm |
100 |
80×80×140 |
|
BXK450/750 |
446 |
1562 |
75 |
22 |
58 |
56.2 |
90.6 |
2.5 |
215 |
80×80×165 |
||
|
BXK450/950 |
446 |
1562 |
100 |
47 |
83 |
95.3 |
131.2 |
2.5 |
230 |
80×80×190 |
||
1.3.2 Material
|
Specifications |
Upper/lower supporting net |
Upper/lower Filter |
Column tube |
Seal ring |
Deflector |
Hardware |
|
BXK450/500 |
PP |
10μm nylon (PA) |
Acrylic |
（EPDM） |
PP |
316L stainless steel |
|
BXK450/750 |
||||||
|
BXK450/950 |
Note: Refer to 5.1 for material chemical stability.
|
Parts |
Cat.No |
Pcs/Packet |
|
BXK450/500（10μm） |
BC916211 |
1 |
|
BXK450/500 |
BC916411 |
1 |
|
BXK450/750（10μm） |
BC918211 |
1 |
|
BXK450/750 |
BC918411 |
1 |
|
BXK450/1000（10μm） |
BC919211 |
1 |
|
BXK450/1000 |
BC919411 |
1 |
|
Adaptor O-ring（450 column） |
BS930012 |
2 |
|
10μm upper filter（450 column） |
BS920012 |
1 |
|
10μm lower filter（450 column） |
BS920032 |
1 |
|
23μm upper filter（450 column） |
BS920022 |
1 |
|
23μm lower filter（450 column） |
BS920042 |
1 |
|
Upper support net（450 column） |
BS920052 |
1 |
|
Lower support net（450 column） |
BS920062 |
1 |
|
Column tube（450/500 column） |
BS916001 |
1 |
|
Column tube（450/750 column） |
BS918001 |
1 |
|
Column tube（450/950 column） |
BS919001 |
1 |
|
Parts |
Cat.No |
Pcs/Packet |
|
450 column adaptor lift up tool |
B-S009 |
1 |
|
450 Lifting Nut |
BS900011 |
1 |
|
Guide plate（450 column） |
BS900021 |
1 |
|
Four-point two-way valve, 10mm |
B-010 |
1 |
|
Four-point four-way valve, 10mm |
BA220021 |
1 |
|
1 "stainless steel clamp |
B-0011 |
1 |
|
BA500016 |
10 |
|
|
Washer（TC25,12.5mm） |
BA500052 |
2 |
|
BA500056 |
10 |
|
|
Blind plate (TC25) |
B-019 |
2 |
|
Blind plate (TC25) |
B-019 |
2 |
|
Blind plate (TC50) |
BA500072 |
2 |
|
Pressure gauge（TC25 connector，6bar） |
BA500081 |
1 |
|
Pressure gauge（TC25 connector，10bar） |
BA500091 |
1 |
|
Three-way（TC25Stainless steel T type） |
BA500101 |
1 |
|
Three-way（2 TC25Stainless steel T type,1 TC50 T type） |
BA500111 |
1 |
|
Pressure gauge（TC50 connector，6bar） |
BA500191 |
1 |
|
Pressure gauge（TC50 connector，10bar） |
BA500181 |
1 |
|
TC joint PVC pipe,6mm,1.5M |
B-0013 |
1 |
|
TC joint PVC pipe,6mm,2M |
BA187001 |
1 |
|
TC joint PVC pipe,10mm,1.5M |
B-0014 |
1 |
|
TC joint PVC pipe,10mm,2M |
BA197001 |
1 |
|
TC connector silicone pipe,6mm,1.5M |
B-0015 |
1 |
|
TC connector silicone pipe, 6mm, 2M |
BA187011 |
1 |
|
TC connector silicone pipe,10mm,1.5M |
B-0016 |
1 |
|
TC connector silicone pipe,10mm,2M |
BA197011 |
1 |
|
Stirrer（150mm plate） |
BA500021 |
1 |
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