Chromatography resins are engineered through coordinated design of the matrix, ligand, and coupling chemistry. Their performance reflects a series of trade-offs among capacity, selectivity, mass transfer, pressure, stability, and scalability. Effective resin selection therefore depends on matching the resin’s design intent and performance boundaries to the specific requirements of capture or polishing processes.

As upstream antibody titers continue to rise, downstream purification faces unprecedented productivity challenges. Although continuous chromatography and membrane chromatography offer important advantages, conventional column chromatography remains the cornerstone of industrial antibody purification because of its high binding capacity, excellent reusability, and superior separation performance.

Exosomes are attracting growing interest in regenerative medicine, cell therapy, and drug delivery. As production moves toward industrialization, scalable purification has become a key challenge. This article reviews the transition from laboratory isolation methods to chromatography-based purification strategies, including SEC, AEX, and mixed-mode chromatography.

This article explores the molecular mechanisms underlying non-specific binding (NSB) in protein chromatography. By examining NSB from the perspectives of molecular thermodynamics and resin–protein interfacial dynamics, it discusses the key factors influencing NSB and practical strategies for minimizing its impact on purification performance.

This joint white paper explores how next-generation Protein A resins enable mild-pH elution, enhanced aggregate control, and greater process flexibility in bispecific antibody purification. Using industrially relevant material, the study demonstrates up to 66.93% aggregate reduction, improved monomer purity, wider operating windows, and robust performance for scalable biomanufacturing.

Learn how antibody purification works — from affinity and ion exchange to HIC and gel filtration. Explore purification workflows, capture strategies, and polishing steps for mAb downstream processing.

This article discusses why higher binding capacity is not always better in antibody affinity chromatography. It explores the trade-offs between DBC, flow rate, selectivity, resin lifetime, and process productivity, emphasizing that resin selection should focus on overall process performance rather than capacity alone.

Pre-activated chromatography resins enable efficient ligand coupling for custom affinity purification, offering flexibility, high specificity, and suitability for diverse biomolecule purification workflows.

In large-scale manufacturing, chromatography resins are not only the core of purification processes, but also critical to cost control and quality assurance. How to select them scientifically?

Ion exchange chromatography resins play a key role in the precise purification of chemical compounds. How do they work? And why have they become indispensable across industries?

This article provides an in-depth analysis of downstream purification strategies for ADCs, the associated technical challenges, and corresponding solutions.

Chromatography, with its high selectivity, scalability, and mild operating conditions, has become a core technology for producing raw materials used in IVD applications.

Diamond Viru-S delivers a more robust solution for virus purification with its high affinity, broad adaptability, and scalable performance.

Affinity chromatography is pivotal for downstream purification of monoclonal antibodies and related formats. The ideal affinity resin balances separation performance (DBC and purity), scale-up compatibility (pressure–flow behavior and alkaline tolerance), and supply reliability (lot-to-lot consistency and supplier capability).

In biopharmaceutical downstream production processes, chromatographic purification has increasingly become an indispensable part, playing an irreplaceable role in improving product purity, impurity removal, and viral clearance. As the core component of these processes, the performance of chromatography resins directly affects product safety and efficacy, and conducting a robust resin storage study is the key step to ensure that the resin maintains stable performance during storage.

Bispecific antibodies (BsAbs) enjoys great potential in tumor immunotherapy as a result of their multi-target mechanism.

What exactly are Protein A affinity resins, and why are they such a big deal in biotech and pharmaceutical manufacturing?

HIC, as the key step in bsAb purification, shows unique advantage in the removal of aggregates. By selecting the right resin type and optimizing processing parameters, it is possible to achieve the efficient separation of target molecules from impurities, leading to high purity and recovery of target proteins. HIC resins play a key role in the scale-up of bsAb production.

Known as "biological missiles" for tumor treatment, Antibody-drug conjugates (ADCs) uses antibodies to target tumor cells and accurately release cytotoxic loads.